Routine ultrasound screening in pregnancy and the children's subsequent
Kieler H; Axelsson O; Haglund B; Nilsson S; Salvesen KA
Department of Obstetrics and Gynecology, Uppsala University, Sweden.
Early Hum Dev, 1998 Jan, 50:2, 233-45
OBJECTIVE: To study a possible association between ultrasound screening
in early pregnancy and altered cerebral dominance measured by the prevalence
of non-right handedness among children, particularly boys. METHODS: Follow-up
of 8 to 9 year old children to women who participated in a randomised controlled
trial on ultrasound screening during pregnancy in 1985-87. The children
were followed up through a questionnaire sent to their mothers. The dominant
hand of the child was assessed by eleven questions. The dominant foot by
one question. RESULTS: No differences were found in non-right handedness
between children in the screening and non-screening group. In separate
analyses on ultrasound exposure and non-right handedness among boys a significant
difference was found (odds ratio 1.33; 95% confidence interval 1.02-1.74).
CONCLUSION: This study could not rule out a possible association between
non-right handedness among boys and ultrasound exposure in early fetal
life. The association was, however, confined to analyses comparing exposed
and non-exposed boys and no associations were found when the comparisons
were performed according to the randomised groups.
MeSH Heading (Major)
Hand|*PH; Laterality|*PH; Prenatal Exposure Delayed Effects|*; Sex Characteristics|*;
Child; Cohort Studies; Confidence Intervals; Female; Follow-Up Studies;
Foot|PH; Human; Male; Odds Ratio; Pregnancy; Questionnaires; Support, Non-U.S.